Abstract The Nuclear receptor 4A (NR4A) subfamily, which Light Meters belongs to the nuclear receptor (NR) superfamily, has three members: NR4A1 (Nur77), NR4A2 (Nurr1) and NR4A3 (Nor1).They are gene regulators with broad involvement in various signaling pathways and human disease responses, including autophagy.Here, we provide a concise Telephone Socket overview of the current understanding of the role of the NR4A subfamily members in human diseases and review the research into their regulation of cell autophagy.
A deeper understanding of these mechanisms has potential to improve drug development processes and disease therapy.